NAME

Sun Ning

School/Department/Center/Institution/Laboratory

Shcool of  Medicine Department of Physiology and Pathophysiology

Post address: 130 DongAn Road, Shanghai 200032, China

E-mail:sunning@fudan.edu.cn

Telephone/Fax :86-21-54237781

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE
(if applicable)

MM/YY FIELD OF STUDY

Fudan University, Shanghai, China
Iowa State University, Ames
Stanford University School of Medicine, Stanford
Fudan University, Shanghai, China

M.D.
Ph.D.
Postdoctoral
Professor

1995-2000
2002-08
2008-13
2013-

Medicine
Molecular, Cellular, and Developmental Biology
Stem Cell Biology and Molecular Imaging
Physiology and Pathophysiology

A. Personal Statement on Research

My current research focuses on the biology of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), hESC/iPSC-derived cardiomyocytes, as well as their applications in cardiac tissue regeneration and cardiovascular diseases.

B. Positions & Honors.
Positions and Employment:
2000-2002 Lecturer, Fudan University School of Medicine
2002-2008 PhD Graduate School, Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University
2008-2013 Postdoctoral Fellow, Institute For Stem Cell Biology and Regenerative Medicine, Department of Medicine & Radiology, Stanford University
2013- Professor, Department of Physiology and Pathophysiology

Professional Membership & Activities:
2004- Member, American Society for Cell Biology
2010- Member, International Society of Stem Cell Research
2011- Member, American Heart Association

Honors and Awards:
2007 American Society for Cell Biology (ASCB) Predoctoral Travel Award
2010-2012 Oak Foundation Cardiovascular Fellowship Award
2012-2014 American Heart Association Western State Postdoctoral Fellowship Award
2013-2015 Organization Department of CPC Central Committee, Global Recruitment for Youth Talents
C. Selected Peer-Reviewed Publications
1. Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC*. Patient-Specific Induced Pluripotent Stem Cell as A Model for Familial Dilated Cardiomyopathy. Science Translational Medicine. 4(130): 130ra47, 2012.(Cover Article)
2. Liu J#, Sun N#, Bruce MA, Wu JC, Butte MJ*. Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes. Plos ONE. 7(5): e37559, 2012. (Co-first Author)
3. Sun N, Longaker MT, Wu JC*. Human iPS Cell-Based Therapy: Considerations before clinical applications. Cell Cycle. 9(5): 1-6, 2010.
4. Sun N, T.W. Huiatt, Z. Li, D. Paulin, R.M. Robson*. Human synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration. Exp Cell Res. 316(3): 491-505, 2010. (Highlighted Article)
5. Sun N, Lee A, Wu JC*. Long term non-invasive imaging of embryonic stem cells using reporter genes. Nature Protocols. 4(8): 1192-1201, 2009.
6. Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC*. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A. 106(37): 15720-15725, 2009.
7. Sun N, Critchley DR, Li Z, Paulin D, Robson RM*. Human Alpha-Synemin Interacts Directly with Vinculin and Metavinculin. Biochem J. 409: 657-667, 2008. (Editorial Commentury)
8. Sun N, Critchley DR, Li Z, Paulin D, Robson RM*. Identification of a Repeated Domain within Mammalian Alpha-Synemin that Interacts Directly with Talin. Exp Cell Res. 314: 1839-1849, 2008.
9. Narsinh HK, Sun N, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Wu JC*. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Journal of Clinical Investigation 121(3): 1217-21, 2011.
10. Wilson KD, Sun N, Huang M, Zhang WY, Lee AS, Li Z, Wang SX, Wu JC*. Effects of ionization on self-renewal and pluripotency of human embryonic stem cells. Cancer Res. 70 (13): 5539-48, 2010.
11. Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, Longaker MT, Wu JC*. A nonviral minicircle vector for deriving human iPS cells. Nature Methods. 7 (3): 197-9, 2010.
12. Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*. Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells with Zinc Finger Nuclease for Cellular Imaging. Circ Res. 111:1494-1503, 2012.
13. Taylor RE, Kim K, Sun N, Park SJ, Sim JY, Fajardo G, Bernstein D, Wu JC, Pruitt BL*. Sacrificial layer technique for axial force post assay of immature cardiomyocytes. Biomedical Microdevices. 2012 Sep 25.
14. Levi B, Hyun JS, Montoro DT, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT*. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc. Natl. Acad. Sci. U.S.A. 109, 20379-84, 2012.
15. Pearl J, Leveson-Gower D, Lee A, Sun N, Negrin R, Wu JC*. Leukocyte Costimulatory Molecule Blockade Permits Allogeneic and Xenogeneic Engraftment of Pluripotent Stem Cells. Cell Stem Cell 8(3): 309-17, 2011.
16. Hammerick KE, Huang Z, Sun N, Lam MT, Prinz FB, Wu JC, Commons GW, Longaker MT*. Elastic Properties of Induced Pluripotent Stem Cells. Tissue Eng Part A. 17(3-4): 495-502, 2011.
17. Levi B, James AW, Nelson ER, Hu S, Sun N, Peng M, Wu J, Longaker MT*. Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 127 (3): 1130-40, 2011.
18. Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC*. MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease. Circulation 122: S124-31, 2010.
19. Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC*. Dynamic MicroRNA Expression Programs during Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499. Circ Cardiovasc Genet. 3(5): 426-35, 2010.
20. Chen MQ, Xie X, Wilson KD, Sun N, Giovangrandi L, Wu JC, Kovacs GT*. Current-controlled electrical point-source stimulation of embryonic stem cells. Cellular and Molecular Bioengineering. 2009; 2(4) 625-635, 2009.
21. Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC*. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells and Development. 18(5): 749-58, 2009.
D. Ongoing Research Support
2012-2014 American Heart Association Western State Postdoctoral Fellowship Award $9,8000
2013-2015 Organization Department of CPC Central Committee, Global Recruitment for Youth Talents, ¥2,000,000